Clinical studies with tubercidin administered by direct intravenous injection.
نویسندگان
چکیده
Tubercidin (NSC 56408), a cytotoxic antibiotic, was used in the treatment of 93 patients with various types of advanced neoplastic disease in a Phase I study to determine human toxicity. Significant toxicity was limited to the observation of nephrotoxicity in 18 cases and local irritation of veins in 12. Tumor response was suggested in only 3 cases, all of which were cases of primary carcinoma of the pancreas.
منابع مشابه
Induction of general anaesthesia with intraosseous injection of thiopental in rabbits
The technique of intraosseous (IO) infusion has been reemerged as an alternative route of intravascular access for the delivery of fluids and some medications. Complications of IO infusion occur rarely and include fractures and osteomyelitis after long-term use of IO access. The purpose of this study was to compare the efficiency of induction of anaesthesia by a standard intravenous route and a...
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Host toxicity of the dose regimen of tubercidin (7-deazaadenosine) plus nitrobenzylthioinosine 5'-monophosphate (NBMPR-P) used in combination therapy of schistosomiasis (M. H. el Kouni, D. Diop, and S. Cha, Proc. Natl. Acad. Sci. USA 80:6667-6670, 1983; M. H. el Kouni, N. J. Messier, and S. Cha, Biochem. Pharmacol. 36:3815-3821, 1987) was examined in vivo in mice and in vitro with human bone ma...
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عنوان ژورنال:
- Cancer research
دوره 30 1 شماره
صفحات -
تاریخ انتشار 1970